Microbiota and mucosal immunity in amphibians
Résumé
We know that animals live in a world dominated by bacteria. In the last 20 years, we have learned that microbes are essential regulators of mucosal immunity. Bacteria, archeas, and viruses influence different aspects of mucosal development and function. Yet, the literature mainly covers findings obtained in mammals. In this review, we focus on two major themes that emerge from the comparative analysis of mammals and amphibians. These themes concern: (i) the structure and functions of lymphoid organs and immune cells in amphibians, with a focus on the gut mucosal immune system; and (ii) the characteristics of the amphibian microbiota and its influence on mucosal immunity. Lastly, we propose to use Xenopus tadpoles as an alternative small-animal model to improve the fundamental knowledge on immunological functions of gut microbiota.
Domaines
Zoologie des vertébrés Biologie moléculaire Génétique animale Génétique des populations [q-bio.PE] Génomique, Transcriptomique et Protéomique [q-bio.GN] Organisation et fonctions cellulaires [q-bio.SC] Interactions cellulaires [q-bio.CB] Embryologie et organogenèse Morphogenèse Bio-Informatique, Biologie Systémique [q-bio.QM] Evolution [q-bio.PE] Systématique, phylogénie et taxonomie| Origine | Publication financée par une institution |
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